Platelet‐rich plasma in treatment of scar, atrophy, and sulcus: Short‐ and long‐term results

Abstract Objective Platelet‐rich plasma (PRP) is rich in growth factors and easily obtained from blood samples. Long‐term data after PRP injection into the larynx should be improved. This study reports short‐term (3 months) long‐term (12 voice results injection. Materials Methods Sixty‐three patients with scars ( n = 34), sulcus vocalis 17), recalcitrant nodules 5), atrophy 4), or a combination of these 3) were included (158 injections; median follow‐up 12.3 months). Stroboscopy, handicap index (VHI‐10), cepstral spectral dysphonia (CSID) before treatment at 12 months tabulated. Results VHI‐10 changed 19.5 to 14 3 21 15 long term. The CSID scores improved 31 short term 26 p < 0.001, paired t ‐test). Patients reported vocal effort stamina slight VHI score changes. Stroboscopy revealed closure mucosal waves. severe less likely improve compared those mild moderate dysphonia. Some showed improvements then deteriorated back baseline over time .05, Conclusion Both short‐ following have been reported. mild‐to‐moderate had better outcomes. an alternative for due fold scarring, sulcus, atrophy. Level evidence II Prospective case series treatment.